Regulatory and societal pressure to reduce antibiotic use in livestock farming is steadily increasing. But how can this transformation succeed in daily operations without compromising animal welfare and profitability? This technical presentation offers a concrete best-practice guide for modern farms. Based on field experience, it shows how to systematically break chains of infection - ranging from drinking water hygiene and continuous cleaning and disinfection protocols to overall barn biosecurity. Attendees will gain actionable checklists and evaluation criteria to pinpoint their farm's weak spots, sustainably reduce medication use, and future-proof herd health.