Tiamulin hydrogen fumarate

Tiamulin hydrogen fumarate is a derivative   of pleuromutilin, can be used in veterinary medicine particularly for pigs   and poultry.It is a diterpene antimicrobial with a pleuromutilin   chemical structure similar to that of valnemulin.

Tiamulin hydrogen fumarate is a   bacteriostatic antibiotic, but it also has bactericidal effect on sensitive   bacteria at very high concentration. The antibacterial mechanism of action is   to inhibit bacterial protein synthesis by binding to the 50s subunit of the   bacterial ribosome.

Tiamulin hydrogen fumarate has   good antibacterial activity against a variety of Gram-positive cocci,   including most staphylococci and streptococci (except group D streptococci)   and a variety of mycoplasmas and some spirochetes. However, the antibacterial   activity against some negative bacteria is very weak, except for Haemophilus   species and some E. coli and Klebsiella strains.

Tiamulin hydrogen fumarate is   easy to be absorbed after oral administration in pigs. About 85% of a single   dose is absorbed, and peak concentrations occur in 2 to 4 hours. It is widely   distributed in the body, with the highest concentration in the lungs.   Tiamulin hydrogen fumarate is metabolized in the body into 20 metabolites,   some with antibacterial tranquility. About 30% of the metabolites are   excreted in the urine and the remainder is excreted in the feces.

Tiamulin hydrogen fumarate is   used for the treatment of swine pneumonia caused by Actinobacillus   pleuropneumoniae and swine blood dysentery caused by Treponema   hyodysenteriae. As a feed drug additive for pigs can promote weight gain. It   is also effective against chronic respiratory disease in chickens, mycoplasma   hyopneumonia, and staphylococcal synovitis in chickens.